Kong K H
Deparment of Physical Medicine, Tan Tock Seng Hospital, Singapore.
Arch Phys Med Rehabil. 1996 Mar;77(3):305-6. doi: 10.1016/s0003-9993(96)90117-3.
Carbamazepine is a drug commonly used in the treatment of neuropathic pain. It is an iminostilbene derivative that is extensively metabolized by the liver. We describe a 66-year-old man with dysesthetic pain from cervical myelopathy who developed cholestatic hepatitis, skin rash, and eosinophilia after carbamazepine was administered for 5 weeks (total dose of 18.9gm). Withdrawal of carbamazepine led to complete resolution of both clinical and biochemical abnormalities within 3 weeks. Clinicians should be alert to this rare complication because it can be confused clinically with biliary tract sepsis and viral hepatitis.
卡马西平是一种常用于治疗神经性疼痛的药物。它是一种亚氨基芪衍生物，在肝脏中广泛代谢。我们描述了一名66岁患有颈髓病感觉异常性疼痛的男性，在服用卡马西平5周（总剂量18.9克）后出现胆汁淤积性肝炎、皮疹和嗜酸性粒细胞增多。停用卡马西平后，临床和生化异常在3周内完全消退。临床医生应警惕这种罕见并发症，因为它在临床上可能与胆道败血症和病毒性肝炎相混淆。
