Rossman C M, Lee R M, Forrest J B, Newhouse M T
Eur J Respir Dis Suppl. 1983;127:64-70.
We studied the ultrastructure and function of nasal cilia from non-atopic and atopic non-smokers, smokers, patients with chronic rhinitis and cystic fibrosis, and compared these to cilia from patients with primary ciliary dyskinesia (PCD). Atypical cilia were found in normal subjects and patients with a variety of chronic respiratory tract diseases, but the proportion was small (less than 5%). Ciliary wave form, beat frequency, and mucociliary transport were normal. In patients with PCD, the proportion of atypical cilia and ultrastructural abnormalities was significantly greater than normal subjects and patients without PCD p less than 0.0001. Beat frequency was reduced, ciliary wave form was grossly abnormal, and mucociliary transport was virtually absent. These findings suggest that ciliary ultrastructural abnormalities are related to altered ciliary function and have aetiological relevance in the generalized chronic respiratory tract disease of PCD.
我们研究了非特应性和特应性非吸烟者、吸烟者、慢性鼻炎和囊性纤维化患者的鼻纤毛超微结构和功能，并将其与原发性纤毛运动障碍（PCD）患者的纤毛进行比较。在正常受试者和患有各种慢性呼吸道疾病的患者中发现了非典型纤毛，但比例较小（小于5%）。纤毛波形、摆动频率和黏液纤毛运输均正常。在PCD患者中，非典型纤毛和超微结构异常的比例显著高于正常受试者和无PCD的患者（p<0.0001）。摆动频率降低，纤毛波形严重异常，黏液纤毛运输几乎不存在。这些发现表明，纤毛超微结构异常与纤毛功能改变有关，并且在PCD的全身性慢性呼吸道疾病中具有病因学相关性。
