Pedersen M
Pediatric Department, State University Hospital, Copenhagen, Denmark.
Lung. 1990;168 Suppl:368-76. doi: 10.1007/BF02718154.
The mucociliary clearance is an important part of the nonspecific defense mechanism of the human airways. Coordinated beats of cilia in the nose, trachea, and bronchi propel the mucous layer toward the pharynx, and with it inhaled microorganisms and other particles captured in the mucus. Normal function of this system depends on the efficacy of the ciliary beating and the properties of mucus. Primary ciliary dyskinesia--a congenital respiratory disease characterized by ultrastructural defects and motility disturbances of cilia--has provided us with valuable information about the role the mucociliary function plays in the protection against harmful agents in the inhaled air. Secondary ciliary dyskinesia is described in inflammatory disorders of the respiratory tract, but also some components in air pollution results in malfunction of cilia, damage of ciliated epithelium, or alteration in the mucus. This review will focus on investigations found in the literature concerning the influence of pollutants on ciliary activity. The methods applied will be evaluated.
黏液纤毛清除是人体气道非特异性防御机制的重要组成部分。鼻腔、气管和支气管中纤毛的协调摆动将黏液层推向咽部，随之将吸入的微生物和捕获在黏液中的其他颗粒一同推进。该系统的正常功能取决于纤毛摆动的效率和黏液的特性。原发性纤毛运动障碍——一种以纤毛超微结构缺陷和运动障碍为特征的先天性呼吸系统疾病——为我们提供了关于黏液纤毛功能在抵御吸入空气中有害物质方面所起作用的宝贵信息。继发性纤毛运动障碍在呼吸道炎症性疾病中也有描述，但空气污染中的一些成分也会导致纤毛功能障碍、纤毛上皮损伤或黏液改变。本综述将聚焦于文献中有关污染物对纤毛活动影响的研究。所应用的方法将得到评估。
