Mygind N, Borum P
Eur J Respir Dis Suppl. 1983;128 (Pt 1):167-74.
As parasympathetic reflexes are of importance for nasal hypersecretion, treatment of rhinorrhoea with a cholino-ceptor antagonist seems rational. We have therefore studied the topically active anti-cholinergic drug ipratropium in laboratory studies and clinical trials. This drug, as a nasal spray, could markedly inhibit metacholine-induced hypersecretion for a prolonged period, in a dosage having no demonstrable systemic effects, in treatment of patients with perennial rhinitis and watery rhinorrhoea as the major symptoms. The daily use of ipratropium spray caused a moderate reduction in the use of handkerchiefs. It is concluded that this new treatment can be of value in such patients, but it is important to realize that the effect is strictly monosymptomatic. Finally, how this type of therapy can be further improved is discussed.
由于副交感神经反射对鼻分泌物过多很重要，因此用胆碱受体拮抗剂治疗鼻漏似乎是合理的。我们因此在实验室研究和临床试验中研究了局部活性抗胆碱能药物异丙托溴铵。这种药物作为鼻喷雾剂，在无明显全身作用的剂量下，可长时间显著抑制乙酰甲胆碱引起的分泌物过多，用于治疗以常年性鼻炎和水样鼻漏为主要症状的患者。每日使用异丙托溴铵喷雾剂可适度减少手帕的使用。得出的结论是，这种新疗法对此类患者可能有价值，但重要的是要认识到其效果严格来说是单症状的。最后，讨论了如何进一步改进这种治疗方法。
