Borum P, Mygind N, Schultz Larsen F
Clin Otolaryngol Allied Sci. 1979 Dec;4(6):407-11. doi: 10.1111/j.1365-2273.1979.tb01773.x.
Eighty micrograms of the topically active parasympatholytic ipratropium were applied intranasally 4 times a day to 20 adult patients with perennial rhinitis and severe watery rhinorrhoea in a double-blind placebo controlled cross-over trial. There was a significant reduction in nasal hypersecretion during ipratropium treatment. Fourteen patients preferred the ipratropium period, 3 the placebo period and 3 had no preference. There were no adverse systemic or local effects. Ipratropium was effective also in patients resistant to glucocorticoids, sodium cromoglycate and antihistaminics. As the drug works immediately it can also be used before exposure to known provocating factors. It is concluded that continuous use of this new medication is of value in the management of severe rhinorrhoea in patients with perennial rhinitis, and that the occasional use is helpful in subjects with infrequent attacks of nasal hypersecretion.
在一项双盲安慰剂对照交叉试验中，对20名患有常年性鼻炎和严重水样鼻漏的成年患者，每天4次经鼻给予80微克局部活性抗胆碱能药物异丙托溴铵。在异丙托溴铵治疗期间，鼻分泌物过多显著减少。14名患者更喜欢使用异丙托溴铵的阶段，3名更喜欢安慰剂阶段，3名无偏好。未出现全身性或局部不良反应。异丙托溴铵对糖皮质激素、色甘酸钠和抗组胺药耐药的患者也有效。由于该药起效迅速，也可在接触已知诱发因素之前使用。得出的结论是，持续使用这种新药对治疗常年性鼻炎患者的严重鼻漏有价值，偶尔使用对鼻分泌物过多发作不频繁的患者有帮助。
