Hausman P B, Moody C E, Innes J B, Gibbons J J, Weksler M E
J Exp Med. 1983 Oct 1;158(4):1307-18. doi: 10.1084/jem.158.4.1307.
Monoclonal antibodies with specificity for autoreactive murine T cells have been developed. These antibodies inhibit proliferative response of splenic T cells activated by syngeneic spleen cells. These antibodies have no effect on the proliferative response of T cells activated by allogeneic spleen cells or PHA. The number of splenic T cells that react with these monoclonal antibodies is comparable in several normal mouse strains.
已经开发出了对自身反应性小鼠T细胞具有特异性的单克隆抗体。这些抗体抑制同基因脾细胞激活的脾T细胞的增殖反应。这些抗体对同种异体脾细胞或PHA激活的T细胞的增殖反应没有影响。在几种正常小鼠品系中,与这些单克隆抗体发生反应的脾T细胞数量相当。