同基因混合淋巴细胞反应的研究。III. 一种对自身反应性T细胞具有特异性的单克隆抗体的研制。
Studies on the syngeneic mixed lymphocyte reaction. III. Development of a monoclonal antibody with specificity for autoreactive T cells.
作者信息
Hausman P B, Moody C E, Innes J B, Gibbons J J, Weksler M E
出版信息
J Exp Med. 1983 Oct 1;158(4):1307-18. doi: 10.1084/jem.158.4.1307.
Abstract
Monoclonal antibodies with specificity for autoreactive murine T cells have been developed. These antibodies inhibit proliferative response of splenic T cells activated by syngeneic spleen cells. These antibodies have no effect on the proliferative response of T cells activated by allogeneic spleen cells or PHA. The number of splenic T cells that react with these monoclonal antibodies is comparable in several normal mouse strains.
摘要
已经开发出了对自身反应性小鼠T细胞具有特异性的单克隆抗体。这些抗体抑制同基因脾细胞激活的脾T细胞的增殖反应。这些抗体对同种异体脾细胞或PHA激活的T细胞的增殖反应没有影响。在几种正常小鼠品系中，与这些单克隆抗体发生反应的脾T细胞数量相当。
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本文引用的文献
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Macrophage heterogeneity in man. A subpopulation of HLA-DR-bearing macrophages required for antigen-induced T cell activation also contains stimulators for autologous-reactive T cells.人类巨噬细胞的异质性。抗原诱导的T细胞活化所需的携带HLA - DR的巨噬细胞亚群也包含自身反应性T细胞的刺激物。
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The role of Ia molecules in the activation of T lymphocytes. III. Antigen-specific, Ia-restricted, interleukin 2-producing T cell hybridomas with detectable affinity for the restricting I-A molecule.Ia分子在T淋巴细胞激活中的作用。III. 对限制性I-A分子具有可检测亲和力的抗原特异性、Ia限制性、产生白细胞介素2的T细胞杂交瘤。
J Exp Med. 1983 Jan 1;157(1):359-64. doi: 10.1084/jem.157.1.359.
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The autologous mixed-lymphocyte reaction.自体混合淋巴细胞反应
Adv Immunol. 1981;31:271-312. doi: 10.1016/s0065-2776(08)60923-2.
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Autologous and syngeneic mixed lymphocyte reactions and their immunological significance.自体和同基因混合淋巴细胞反应及其免疫学意义。
Prog Allergy. 1981;28:160-92.
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Lymphocyte transformation induced by autologous cells. X. Soluble factors that generate cytotoxic T lymphocytes.自体细胞诱导的淋巴细胞转化。X. 产生细胞毒性T淋巴细胞的可溶性因子。
J Exp Med. 1980 Aug 1;152(2 Pt 2):284s-291s.
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The autologous mixed lymphocyte reaction in strains of mice with autoimmune disease.患有自身免疫性疾病的小鼠品系中的自体混合淋巴细胞反应。
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Lymphocyte transformation induced by autologous cells. XV. Xenoantigens are not required for the proliferative response observed in the autologous mixed lymphocyte reaction.自体细胞诱导的淋巴细胞转化。十五。自体混合淋巴细胞反应中观察到的增殖反应不需要异种抗原。
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