Ia分子在T淋巴细胞激活中的作用。III. 对限制性I-A分子具有可检测亲和力的抗原特异性、Ia限制性、产生白细胞介素2的T细胞杂交瘤。
The role of Ia molecules in the activation of T lymphocytes. III. Antigen-specific, Ia-restricted, interleukin 2-producing T cell hybridomas with detectable affinity for the restricting I-A molecule.
作者信息
Rock K L, Benacerraf B
出版信息
J Exp Med. 1983 Jan 1;157(1):359-64. doi: 10.1084/jem.157.1.359.
Abstract
Antigen-specific I region-restricted, interleukin 2-producing T cell hybridomas were produced by fusing GAT-specific T cell blasts with BW5147. Two antigen-specific phenotypes were identified, one autoreactive and one nonautoreactive. All of the antigen-specific and autoreactive clones were H-2 restricted, mapping to the IA subregion by genetic analysis and monoclonal antibody inhibition. Both the antigen-specific and autoreactive stimulation are the property of a single cell and required no known exogenous antigens.
摘要
通过将针对谷氨酸-丙氨酸-酪氨酸（GAT）的特异性T细胞母细胞与BW5147细胞融合，制备出了抗原特异性的、受I区限制的、产生白细胞介素2的T细胞杂交瘤。鉴定出了两种抗原特异性表型，一种是自身反应性的，一种是非自身反应性的。所有抗原特异性和自身反应性克隆均受H-2限制，通过遗传分析和单克隆抗体抑制确定其定位于IA亚区。抗原特异性刺激和自身反应性刺激都是单个细胞的特性，不需要已知的外源性抗原。
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本文引用的文献
1
Specificity of T-cell cones illustrates altered self hypothesis.T细胞克隆型的特异性说明了自身改变假说。
Nature. 1981 Dec 3;294(5840):460-2. doi: 10.1038/294460a0.
2
Alloreactivity of an antigen-specific T-cell clone.抗原特异性T细胞克隆的同种异体反应性。
Nature. 1980 Oct 30;287(5785):855-7. doi: 10.1038/287855a0.
3
The role of Ia molecules in the activation of T lymphocytes. I. The activation of an IL 1-dependent IL 2-producing T cell hybridoma by Con A requires an interaction, which is not H-2-restricted, with an Ia-bearing accessory cell.Ia分子在T淋巴细胞激活中的作用。I. 伴刀豆球蛋白A激活IL-1依赖的产生IL-2的T细胞杂交瘤需要与表达Ia的辅助细胞进行非H-2限制性的相互作用。
J Immunol. 1982 Oct;129(4):1360-6.
4
Ia-dependent interleukin 2 production in syngeneic cellular interactions.同基因细胞相互作用中Ia依赖性白细胞介素2的产生
J Immunol. 1982 Jan;128(1):480-5.
5
Antigen-reactive T cells can be activated buy autologous macrophages in the absence of added antigen.在不添加抗原的情况下，抗原反应性T细胞可被自体巨噬细胞激活。
J Exp Med. 1981 Feb 1;153(2):476-81. doi: 10.1084/jem.153.2.476.
6
Production of autoreactive I region-restricted T cell hybridomas.自身反应性I区限制T细胞杂交瘤的产生。
J Exp Med. 1982 Aug 1;156(2):640-5. doi: 10.1084/jem.156.2.640.
7
Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules.小鼠同基因混合淋巴细胞反应。I. 靶抗原是自身Ia分子。
J Exp Med. 1981 Nov 1;154(5):1652-70. doi: 10.1084/jem.154.5.1652.
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Nature. 1975 Jul 31;256(5516):419-21. doi: 10.1038/256419a0.
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