Walker V, Smythe P J, Cook N J, Ball N A, Veall R M, Whiteman P
J Ment Defic Res. 1983 Jun;27 (Pt 2):105-14. doi: 10.1111/j.1365-2788.1983.tb00283.x.
Urine from 348 patients of a hospital for the mentally handicapped in Wessex was screened for abnormalities of aminoacid and mucopolysaccharide excretion. Persistent aminoacid abnormalities were found in 16 patients: two had phenylketonuria and one a severe variant form of hyperphenylalaninaemia (dihydropteridine reductase deficiency). In at least nine of the other patients, the observed abnormality was probably a secondary phenomenon. Two patients excreted excessive amounts of a glycosaminoglycan identified tentatively as hyaluronic acid. The study also uncovered one undiagnosed diabetic and three patients with urinary tract infection.
对韦塞克斯一家智障医院的348名患者的尿液进行了氨基酸和黏多糖排泄异常筛查。在16名患者中发现了持续性氨基酸异常：2名患有苯丙酮尿症，1名患有严重的高苯丙氨酸血症变异型（二氢蝶啶还原酶缺乏症）。在至少其他9名患者中，观察到的异常可能是一种继发现象。2名患者排泄出过量的一种暂定为透明质酸的糖胺聚糖。该研究还发现了1例未确诊的糖尿病患者和3例尿路感染患者。
