Marrs R P, Vargyas J M, Gibbons W E, Saito H, Mishell D R
Am J Obstet Gynecol. 1983 Oct 1;147(3):318-22. doi: 10.1016/0002-9378(83)91118-3.
Forty-seven ovulatory women were treated with a modified technique of human in vitro fertilization and embryo transfer. All patients received clomiphene citrate, 150 mg per day, and follicle development was monitored by real-time ovarian ultrasound and serum estradiol measurement. In the 45 patients who underwent laparoscopy, eight patients were found to have a poor response to clomiphene citrate and were dropped from the treatment cycle. Four additional patients had an endogenous luteinizing hormone increase and did not undergo laparoscopy. Nine patients were found to have inaccessible ovaries at the time of laparoscopy. In patients with accessible ovaries, oocytes were recovered in all cases. Embryo transfers were performed in 72% of patients, and 19% of these transfers resulted in pregnancy. This technique of ovulation monitoring appears to increase oocyte recovery and fertilization rate and subsequent implantation success.
47名有排卵功能的女性接受了改良的人类体外受精和胚胎移植技术治疗。所有患者均接受枸橼酸氯米芬治疗，每日150毫克，通过实时卵巢超声和血清雌二醇测量监测卵泡发育情况。在接受腹腔镜检查的45例患者中，发现8例对枸橼酸氯米芬反应不佳，被排除在治疗周期之外。另有4例患者内源性促黄体生成素升高，未接受腹腔镜检查。9例患者在腹腔镜检查时发现卵巢无法触及。在卵巢可触及的患者中，所有病例均成功获取了卵母细胞。72%的患者进行了胚胎移植，其中19%的移植成功妊娠。这种排卵监测技术似乎提高了卵母细胞回收率、受精率及随后的着床成功率。
