van der Merwe J V, Irsigler U M, de Milander C, Wimmers M S, Botes A D, Snyman E, von Prince M S, Koch Z, Hurter P
S Afr Med J. 1984 Oct 27;66(17):641-4.
Details of the in vitro fertilization and embryo transfer programme at the Department of Obstetrics and Gynaecology of the H. F. Verwoerd Hospital and the University of Pretoria are presented. From 1 March 1982 to 30 November 1983, 67 cycles in 47 patients were induced using clomiphene citrate and human chorionic gonadotrophin (hCG) (46 patients) and human postmenopausal gonadotrophin/hCG (1 patient). In 5 patients ovum recovery was unsuccessful owing to severe adhesions. In the remaining 42 patients 59 oocyte recoveries out of a total of 62 attempts were successful, a 95% recovery rate. One hundred and seventy-nine ova were recovered (2,9 per laparoscopy), of which 143 (80%) were viable. Forty-six per cent of fertilized ova cleaved actively. Forty-one transfers of 66 embryos (average 1,6 embryos per transfer) resulted in 5 pregnancies (12% pregnancy rate per transfer). Three preclinical pregnancies aborted spontaneously. Two pregnancies are ongoing at 30 and 32 weeks' gestation. Thus, the programme has so far led to 2 third-trimester pregnancies. Consolidation and refinement of techniques should lead to a steady increase in success at this centre.
本文介绍了位于比勒陀利亚大学H.F.沃沃德医院妇产科的体外受精和胚胎移植项目的详细情况。从1982年3月1日至1983年11月30日，47名患者接受了67个周期的治疗，其中46名患者使用枸橼酸氯米芬和人绒毛膜促性腺激素（hCG）诱导排卵，1名患者使用人绝经后促性腺激素/hCG诱导排卵。5名患者因严重粘连导致取卵失败。其余42名患者在62次取卵尝试中共成功取卵59次，成功率为95%。共取出179枚卵子（每次腹腔镜检查平均取出2.9枚），其中143枚（80%）存活。46%的受精卵积极分裂。66枚胚胎进行了41次移植（每次移植平均1.6枚胚胎），共5例妊娠（每次移植妊娠率为12%）。3例临床前妊娠自然流产。2例妊娠分别处于妊娠30周和32周，仍在继续。因此，该项目目前已实现2例孕晚期妊娠。技术的巩固和完善应会使该中心的成功率稳步提高。
