Mitchison N A, Pettersson S
Ann Immunol (Paris). 1983 Jul-Aug;134D(1):37-45. doi: 10.1016/s0769-2625(83)80054-3.
Several lines of evidence indicate that T cells proliferate in response to antigenic stimulation to only a very limited extent, and certainly markedly less than do B cells. We here summarize new evidence showing (1) that even under conditions of in vivo immunization, T cells rapidly reach a plateau of activity which does not rise even upon repeated stimulation, and (2) that the plateau is reached so rapidly that the initial frequency of responding cells must be high. Our evidence for these conclusions comes from studies on adoptive immunization in which the activity of T cells activated in vivo and cell lines selected in vitro are compared.
多项证据表明，T细胞对抗原刺激的增殖反应程度非常有限，肯定明显低于B细胞。我们在此总结新的证据，这些证据表明：（1）即使在体内免疫的条件下，T细胞也会迅速达到活性平台期，即使反复刺激也不会升高；（2）达到平台期的速度非常快，以至于反应细胞的初始频率一定很高。我们得出这些结论的证据来自对过继免疫的研究，在该研究中比较了体内激活的T细胞和体外选择的细胞系的活性。
