Smith M D, Hardy G, Williams J D, Coles G A
Clin Nephrol. 1983 Sep;20(3):130-5.
Suppressor cell activity was studied in 30-non-transfused renal dialysis patients using the Concanavalin A enhancement method. Suppressor cell numbers were estimated in 19 patients by the T suppressor (T gamma) rosette technique and in 15 patients using a monoclonal antibody (OKT8) specific for T suppressor cells. The role of prostaglandin secreting monocytes in the observed suppression was investigated in 6 patients using the prostaglandin secreting inhibitor flurbiprofen. Both suppressor cell numbers and activity were either normal or low compared with normal healthy controls. Flurbiprofen at concentrations of 10(-4) and 10(-6) M caused a decrease in activity in both patients and normal controls. The results indicate that the increased suppressor cell activity and number reported in dialysis patients may be due to the effect of blood transfusion previously administered to the patients.
采用伴刀豆球蛋白A增强法，对30例未输血的肾透析患者的抑制细胞活性进行了研究。通过T抑制（Tγ）玫瑰花结技术对19例患者的抑制细胞数量进行了估计，对15例患者使用针对T抑制细胞的单克隆抗体（OKT8）进行了研究。使用前列腺素分泌抑制剂氟比洛芬，对6例患者观察到的抑制作用中前列腺素分泌单核细胞的作用进行了研究。与正常健康对照相比，抑制细胞数量和活性均正常或较低。浓度为10(-4)和10(-6)M的氟比洛芬导致患者和正常对照的活性均下降。结果表明，透析患者中报道的抑制细胞活性和数量增加可能归因于先前给予患者的输血影响。
