Graham G D, Lundy M M, Moreno A J, Frederick R J
Clin Nucl Med. 1983 Aug;8(8):344-6. doi: 10.1097/00003072-198308000-00004.
Twenty rabbits with chronic osteomyelitis of the tibia were treated for eight weeks and then scanned with Tc-99m MDP and Ga-67 citrate. All were sacrificed and bacteriologic cultures of the tibia were obtained. All rabbits had positive Tc-99m MDP scans at the end of treatment despite thirteen cures of osteomyelitis. Eight had negative gallium scans and negative cultures. Five of the twelve positive gallium scans had negative cultures, while seven had positive cultures. Tc-99m MDP alone is not sensitive enough to be useful in predicting the cure of osteomyelitis, and combining Tc-99m MDP and Ga-67 citrate scintigrams offers no additional information over the Ga-67 citrate scintigram alone in follow-up of osteomyelitis.
对20只患有胫骨慢性骨髓炎的兔子进行了为期8周的治疗，然后用锝-99m亚甲基二膦酸盐（Tc-99m MDP）和枸橼酸镓-67（Ga-67）进行扫描。所有兔子均被处死，并获取胫骨的细菌培养物。尽管有13只兔子的骨髓炎得到治愈，但在治疗结束时所有兔子的Tc-99m MDP扫描结果均为阳性。8只兔子的镓扫描结果为阴性且培养物为阴性。12只镓扫描结果为阳性的兔子中，5只培养物为阴性，7只培养物为阳性。单独使用Tc-99m MDP在预测骨髓炎治愈方面不够敏感，在骨髓炎的随访中，将Tc-99m MDP和Ga-67枸橼酸盐闪烁扫描相结合，相比单独使用Ga-67枸橼酸盐闪烁扫描并不能提供更多信息。
