Bacon E R, Sing A P, Reinish C L
Exp Hematol. 1983 Sep;11(8):747-56.
Regulation of granulopoiesis by activated splenic T lymphocyte subpopulations was investigated. The addition of syngeneic T cells activated by the mitogen concanavalin A or by mixed lymphocyte response (MLR) to normal bone marrow cultures stimulated granulopoiesis, while, in contrast, resting T cells did not. Functional analyses of Fluorescence Activated Cell Sorter (FACS) purified subpopulations of MLR activated T cells showed that both subsets enhanced granulocyte colony forming cells (CFUc) differentiation. Further studies using Ly 23+ T cells stimulated in vitro to suppress the primary generation of plaque forming cells (PFC) showed that these "suppressor cells" simultaneously enhanced CFUc differentiation. These results show that T cell "helper" function in hematopoietic regulation is not restricted to the inducer subset of T cells.
研究了活化的脾T淋巴细胞亚群对粒细胞生成的调节作用。将由丝裂原刀豆球蛋白A或混合淋巴细胞反应（MLR）激活的同基因T细胞添加到正常骨髓培养物中，可刺激粒细胞生成，而相比之下，静止T细胞则无此作用。对荧光激活细胞分选仪（FACS）纯化的MLR激活T细胞亚群进行功能分析表明，两个亚群均增强了粒细胞集落形成细胞（CFUc）的分化。使用体外刺激的Ly 23 + T细胞抑制斑块形成细胞（PFC）的初次生成的进一步研究表明，这些“抑制细胞”同时增强了CFUc的分化。这些结果表明，T细胞在造血调节中的“辅助”功能并不局限于T细胞的诱导亚群。
