Hoffenbach A, Lagrange P H, Bach M A
Clin Exp Immunol. 1983 Oct;54(1):151-7.
C57BL/6 were infected intravenously with 10(7) Mycobacterium lepraemurium (MLM). At increasing time intervals after infection different isolated splenic cell subpopulations were tested for their ability to suppress the mixed lymphocyte reaction (MLR) of normal syngeneic mouse splenocytes. During the first 6 months after infection neither T depleted nor plastic adherent spleen cells from infected mice exerted a suppressive activity on the normal mouse allogeneic proliferative response. Conversely, splenic T cells from MLM infected mice exhibited suppressive activity as early as 2 months after infection. Attempts to characterize the Lyt phenotype of splenic suppressor T cells from 6 months infected mice showed that both Lyt 1+ 2- and Lyt 2+ enriched cell subsets possessed the ability to suppress the MLR of the normal mouse spleen cells and Lyt 1+ 2- T cells were shown to be more efficient suppressors than Lyt 2+ cells.
将10⁷ 鼠麻风杆菌（MLM）静脉注射到C57BL/6小鼠体内。在感染后的不同时间间隔，检测分离出的不同脾细胞亚群抑制正常同基因小鼠脾细胞混合淋巴细胞反应（MLR）的能力。在感染后的前6个月，感染小鼠的T细胞耗竭或塑料黏附脾细胞均未对正常小鼠的同种异体增殖反应发挥抑制活性。相反，感染MLM的小鼠脾T细胞在感染后2个月就表现出抑制活性。对感染6个月小鼠的脾抑制性T细胞的Lyt表型进行鉴定的尝试表明，Lyt 1⁺ 2⁻ 和富含Lyt 2⁺ 的细胞亚群均具有抑制正常小鼠脾细胞MLR的能力，且Lyt 1⁺ 2⁻ T细胞被证明是比Lyt 2⁺ 细胞更有效的抑制细胞。
