Sakuntala R, Pratap V K, Sharma N K, Dayal S S
Lepr India. 1983 Apr;55(2):252-60.
Uniform accumulation of acid mucopolysaccharides in all types of leprosy lesions was seen, except late tuberculoid lesions which showed the accumulation only at the periphery. Absence of acid mucopolysaccharides was significant in well formed epithelioid granulomas and in giant cells of late tuberculoid cases. Generally a progressive decrease with advancing chronicity of the disease was noted. The dermal zone without any cellular infiltrate showed abundant acid mucopolysaccharides in comparison to those areas having inflammatory cell infiltrate in 70.83% of LL, 42.86% of BL, 33.3% of BB, 40.0% of BT, and 13.51% of TT cases. In Indeterminate cases the distribution was same to that of control cases. Testicular hyaluronidase digestion established that hyaluronic acid constituted the main bulk of acid mucopolysaccharides. The possible source of hyaluronic acid is discussed.
在所有类型的麻风病损害中均可见酸性粘多糖的均匀积聚，但晚期结核样型损害仅在周边显示积聚。在成熟的上皮样肉芽肿和晚期结核样型病例的巨细胞中，酸性粘多糖缺失显著。一般而言，随着疾病慢性化进展，酸性粘多糖呈逐渐减少趋势。在70.83%的瘤型、42.86%的界线类偏瘤型、33.3%的中间界线类、40.0%的界线类偏结核样型以及13.51%的结核样型病例中，与有炎性细胞浸润的区域相比，无任何细胞浸润的真皮区显示有丰富的酸性粘多糖。在未定类病例中，其分布与对照病例相同。睾丸透明质酸酶消化证实透明质酸构成了酸性粘多糖的主要部分。文中讨论了透明质酸的可能来源。
