Hollingsworth M A, Evans D L
Mech Ageing Dev. 1983 Jul-Aug;22(3-4):321-33. doi: 10.1016/0047-6374(83)90086-6.
New Zealand Black rats are shown to have a mean longevity of 102.9 weeks. The 90%, 50% and 10% survival age are 81 weeks, 108 weeks and 126 weeks, respectively. Resistance to syngeneic tumor challenge is significantly lower in young rats (3-35 weeks) and very old rats (126-140 weeks) compared to middle-aged rats (36-85 weeks). The in vitro spleen cell proliferative response to syngeneic tumor cells is decreased in old rats. No decrease is observed in spleen cell proliferation induced by the mitogens concanavalin A or phytohemagglutinin. Young (4 weeks) rat spleens contain suppressor cells which affect the mitogen and syngeneic tumor cell induced proliferation of responsive spleen cells (from 50-week-old rats). Spleen cells from old rats (130 weeks) do not demonstrate analogous suppressor cell activity.
新西兰黑鼠的平均寿命为102.9周。90%、50%和10%的存活年龄分别为81周、108周和126周。与中年大鼠（36 - 85周）相比，年轻大鼠（3 - 35周）和非常年老的大鼠（126 - 140周）对同基因肿瘤攻击的抵抗力显著降低。老年大鼠对同基因肿瘤细胞的体外脾细胞增殖反应降低。在由促细胞分裂剂刀豆球蛋白A或植物血凝素诱导的脾细胞增殖中未观察到降低。年轻（4周）大鼠的脾脏含有抑制细胞，这些细胞会影响促细胞分裂剂和同基因肿瘤细胞诱导的反应性脾细胞（来自50周龄大鼠）的增殖。老年大鼠（130周）的脾细胞未表现出类似的抑制细胞活性。
