Radcliffe J D, Moon R C
Proc Soc Exp Biol Med. 1983 Nov;174(2):270-5. doi: 10.3181/00379727-174-41736.
Food intake and growth were depressed during the first week of feeding the anticarcinogenic retinoid N-(4-hydroxyphenyl) retinamide (HPR) at a concentration of 782 mg/kg diet to female rats. Food intake was normalized thereafter, but body weight did not reach that of control animals until 40 days later. The use of a pair-fed group demonstrated that weight depression in HPR fed animals was entirely due to reduced food intake. Mammary glands from HPR-fed animals showed decreased ductal branching and decreased end bud proliferation relative to control glands. Total hepatic retinol and retinol concentration were lower (P less than 0.05) for HPR fed animals than for controls. The effects of HPR on mammary development and retinol storage were attributable to dietary HPR per se. HPR was detected in mammary gland and body fat at concentrations of 27 and 53.7 nmol/g, respectively.
给雌性大鼠喂食浓度为782毫克/千克日粮的抗癌类视黄醇N-(4-羟基苯基)视黄酰胺（HPR），在喂食的第一周，食物摄入量和生长受到抑制。此后食物摄入量恢复正常，但直到40天后体重才达到对照动物的水平。采用配对喂食组表明，喂食HPR的动物体重下降完全是由于食物摄入量减少。与对照腺体相比，喂食HPR的动物的乳腺导管分支减少，终末芽增殖减少。喂食HPR的动物肝脏中的总视黄醇和视黄醇浓度低于对照组（P<0.05）。HPR对乳腺发育和视黄醇储存的影响归因于日粮中的HPR本身。在乳腺和体脂中检测到的HPR浓度分别为27和53.7纳摩尔/克。
