Nagy L, Tóth A
Allerg Immunol (Leipz). 1983;29(3):145-8.
Airways response to inhaled acetylcholine was studied in asthmatic patients with negative and positive response to exercise. The respiratory threshold of acetylcholine proved to be lower in exercise-responders. Mean value of the bronchoconstrictive dose of acetylcholine was found 72 +/- 78 micrograms in patients with positive, while 510 +/- 360 micrograms in those with negative response to exercise challenge. Our data seem to confirm previous hypotheses, i.e. that exercise-induced asthma is a phenomenon dependent on two factors: mediators generated during exercise (histamine, catecholamines, neutrophil chemotactic factor) and a vagal response from the bronchi.
对运动有阴性和阳性反应的哮喘患者进行了气道对吸入乙酰胆碱反应的研究。结果证明，运动反应者中乙酰胆碱的呼吸阈值较低。运动激发试验阳性患者中乙酰胆碱支气管收缩剂量的平均值为72±78微克，而运动激发试验阴性患者中该值为510±360微克。我们的数据似乎证实了先前的假设，即运动诱发的哮喘是一种依赖于两个因素的现象：运动过程中产生的介质（组胺、儿茶酚胺、中性粒细胞趋化因子）和来自支气管的迷走神经反应。
