Rufin P, Benoist M R, Jean R, Scheinmann P, Paupe J
Nouv Presse Med. 1980 Apr 26;9(19):1357-60.
Fifty asthmatic children were tested for cholinergic bronchial sensitivity and subjected to a free running exercise test; 92% of them showed hypersensitivity to acetylcholine challenge, and exercise-induced bronchospasm occurred in 80%. On pooling the results, 98% had a positive response to at least one of the tests. Qualitatively, there was a correlation between exercise-induced bronchospasm and bronchial sensitivity to acetylcholin in 38 of the 50 children. Quantitatively, however, no correlation could be found between the severity of the exercise-induced bronchospasm and the threshold dose of acetylcholin. This could be explained by the fact that the non-immunological spasmogenic mechanisms involved in the two tests are different.
对50名哮喘儿童进行了胆碱能支气管敏感性测试，并进行了自由运动试验；其中92%对乙酰胆碱激发试验表现出超敏反应，80%发生了运动诱发性支气管痉挛。综合结果，98%对至少一项测试呈阳性反应。定性分析，50名儿童中有38名运动诱发性支气管痉挛与支气管对乙酰胆碱的敏感性之间存在相关性。然而，定量分析发现运动诱发性支气管痉挛的严重程度与乙酰胆碱的阈值剂量之间没有相关性。这可以用两项测试中涉及的非免疫性痉挛性机制不同来解释。
