Williamson W D, Desmond M M, Wilson G S, Murphy M A, Rozelle J, Garcia-Prats J A
Am J Dis Child. 1983 Dec;137(12):1181-4. doi: 10.1001/archpedi.1983.02140380041014.
Twenty-nine low-birth-weight infants who survived neonatal intraventricular hemorrhage (IVH) were followed up prospectively and were last examined at a mean age of 3 1/2 years. The mean gestational age (+/- SD) of the group was 28.9 weeks (+/- 2.4 weeks), and the mean birth weight (+/- SD) was 1,167 g (+/- 292 g). Ten patients (34%) had normal neurologic outcome, and four (14%) had minimal abnormalities. Nine children (31%) were categorized as moderately abnormal, and six (21%) had severe abnormalities on neurologic examination. Intellectual performance was normal for 14 patients (48%), mildly delayed for seven (24%), and in the retarded range for eight (28%). Twelve children (41%), at 3 years of age, had handicapping conditions severe enough to warrant admission to special education programs in the public school. The grade of IVH was related significantly to neurologic outcome; both grade of hemorrhage and birth weight were correlated significantly with need for special education. Intellectual performance was related not only to grade of hemorrhage and birth weight, but also to paternal social class.
对29例新生儿脑室内出血（IVH）存活的低体重儿进行了前瞻性随访，最后一次检查时的平均年龄为3.5岁。该组的平均胎龄（±标准差）为28.9周（±2.4周），平均出生体重（±标准差）为1167克（±292克）。10例患者（34%）神经功能结局正常，4例（14%）有轻微异常。9名儿童（31%）被归类为中度异常，6名（21%）在神经检查时有严重异常。14例患者（48%）智力表现正常，7例（24%）轻度延迟，8例（28%）处于智力发育迟缓范围。12名儿童（41%）在3岁时，有严重到足以进入公立学校特殊教育项目的残疾状况。IVH的分级与神经功能结局显著相关；出血分级和出生体重均与特殊教育需求显著相关。智力表现不仅与出血分级和出生体重有关，还与父亲的社会阶层有关。
