大黄素甲醚对从大鼠肝脏分离的线粒体中氧化磷酸化和Ca2+诱导的肿胀的抑制作用。
Inhibition by secalonic acid D of oxidative phosphorylation and Ca2+-induced swelling in mitochondria isolated from rat livers.
作者信息
Kawai K, Nakamaru T, Maebayashi Y, Nozawa Y, Yamazaki M
出版信息
Appl Environ Microbiol. 1983 Oct;46(4):793-6. doi: 10.1128/aem.46.4.793-796.1983.
Abstract
The in vitro biological activity of secalonic acid D, a mycotoxin from Aspergillus ochraceus, was studied to assess its cytotoxicity for isolated rat liver mitochondria. Secalonic acid D uncoupled the oxidative phosphorylation of mitochondria and caused a mild inhibition of state 3 respiration. Secalonic acid D weakly enhanced latent ATPase activity in mitochondria but suppressed 2,4-dinitrophenol-stimulated ATPase activity. Secalonic acid D did not induce pseudoenergized swelling of mitochondria and markedly inhibited the Ca2+-induced swelling of mitochondria in KCl isotonic solution.
摘要
对曲霉属真菌产生的霉菌毒素——柄曲霉素D的体外生物活性进行了研究，以评估其对分离的大鼠肝线粒体的细胞毒性。柄曲霉素D使线粒体的氧化磷酸化解偶联，并对状态3呼吸产生轻度抑制。柄曲霉素D微弱增强了线粒体中的潜在ATP酶活性，但抑制了2,4-二硝基苯酚刺激的ATP酶活性。柄曲霉素D未诱导线粒体的假能化肿胀，且在氯化钾等渗溶液中显著抑制了钙离子诱导的线粒体肿胀。
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