柄曲霉素和5,6-二甲氧基柄曲霉素对线粒体中ATP合成的抑制作用。
Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria.
作者信息
Kawai K, Nakamaru T, Nozawa Y, Maebayashi Y, Yamazaki M, Natori S
出版信息
Appl Environ Microbiol. 1984 Nov;48(5):1001-3. doi: 10.1128/aem.48.5.1001-1003.1984.
Abstract
The inhibitory effects of sterigmatocystin, O-methylsterigmatocystin, and 5,6-dimethoxysterigmatocystin on the ATP synthesis system in mitochondria were compared with that of aflatoxin B1, which disturbs the respiratory chain in mitochondria. Sterigmatocystin and 5,6-dimethoxysterigmatocystin were found to uncouple the oxidative phosphorylation process without causing depression of state 3 respiration. O-Methylsterigmatocystin did not exhibit uncoupling activity at the limited concentrations tested (due to its low solubility in an aqueous system). These compounds, as well as aflatoxin B1, elicited neither pseudo-energized nor energized swelling of mitochondria and did not inhibit Ca2+-induced swelling of mitochondria.
摘要
将柄曲霉素、O-甲基柄曲霉素和5,6-二甲氧基柄曲霉素对线粒体中ATP合成系统的抑制作用与黄曲霉毒素B1进行了比较，黄曲霉毒素B1会干扰线粒体中的呼吸链。结果发现，柄曲霉素和5,6-二甲氧基柄曲霉素可使氧化磷酸化过程解偶联，而不会导致状态3呼吸的抑制。在所测试的有限浓度下，O-甲基柄曲霉素未表现出解偶联活性（由于其在水体系中的低溶解度）。这些化合物以及黄曲霉毒素B1既不会引起线粒体的假激发肿胀也不会引起激发肿胀，并且不会抑制Ca2+诱导的线粒体肿胀。
相似文献
1
Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria.柄曲霉素和5,6-二甲氧基柄曲霉素对线粒体中ATP合成的抑制作用。
Appl Environ Microbiol. 1984 Nov;48(5):1001-3. doi: 10.1128/aem.48.5.1001-1003.1984.
2
Genotoxic effects of a variety of sterigmatocystin-related compounds in the hepatocyte/DNA-repair test and the Salmonella microsome assay.多种柄曲霉素相关化合物在肝细胞/DNA修复试验和沙门氏菌微粒体试验中的遗传毒性作用。
Mutat Res. 1986 Mar;173(3):217-22. doi: 10.1016/0165-7992(86)90039-4.
3
Mutagenicity of 5,6-dimethoxysterigmatocystin, a metabolite from Aspergillus multicolor, in the Salmonella/microsome system.来自杂色曲霉的代谢产物5,6-二甲氧基柄曲霉素在沙门氏菌/微粒体系统中的致突变性。
Appl Environ Microbiol. 1979 Nov;38(5):1015-7. doi: 10.1128/aem.38.5.1015-1017.1979.
4
The effects of O-acetylsterigmatocystin and related compounds on rat liver and cultured chicken embryonal liver cells.O-乙酰基柄曲霉素及相关化合物对大鼠肝脏和培养的鸡胚肝细胞的影响。
Chem Biol Interact. 1975 Dec;11(6):507-22. doi: 10.1016/0009-2797(75)90027-7.
5
Inhibition by secalonic acid D of oxidative phosphorylation and Ca2+-induced swelling in mitochondria isolated from rat livers.大黄素甲醚对从大鼠肝脏分离的线粒体中氧化磷酸化和Ca2+诱导的肿胀的抑制作用。
Appl Environ Microbiol. 1983 Oct;46(4):793-6. doi: 10.1128/aem.46.4.793-796.1983.
6
Functional state of rat liver and kidney mitochondria during sterigmatocystin toxicosis.柄曲霉素中毒时大鼠肝脏和肾脏线粒体的功能状态
Indian J Exp Biol. 1988 Nov;26(11):858-9.
7
[Effect of rubratoxin B on the respiration of liver mitochondria in the rat].[红天精毒素B对大鼠肝脏线粒体呼吸的影响]
Mycopathologia. 1975 Feb 28;55(1):53-5. doi: 10.1007/BF00467092.
8
Effect of sterigmatocystin, a carcinogenic mycotoxin, on urea cycle enzymes and related metabolites in rat liver.致癌霉菌毒素柄曲霉素对大鼠肝脏尿素循环酶及相关代谢物的影响。
Indian J Biochem Biophys. 1987 Feb;24(1):51-3.
9
Influence of the energetic state of mitochondria on the inhibition of oxidative phosphorylation by N-ethylmaleimide.线粒体能量状态对N-乙基马来酰亚胺抑制氧化磷酸化的影响。
Biochim Biophys Acta. 1979 May 9;546(2):356-64. doi: 10.1016/0005-2728(79)90053-7.
10
Influence of the anesthetic 2,6-diisopropylphenol on the oxidative phosphorylation of isolated rat liver mitochondria.麻醉剂2,6-二异丙基苯酚对离体大鼠肝线粒体氧化磷酸化的影响。
Biochem Pharmacol. 1991 Jun 21;42(1):87-90. doi: 10.1016/0006-2952(91)90684-w.
引用本文的文献
1
Sterigmatocystin in foodstuffs and feed: aspects to consider.食品和饲料中的柄曲霉素：需考虑的方面。
Mycology. 2018 Jul 9;11(2):91-104. doi: 10.1080/21501203.2018.1492980.
2
Sterigmatocystin moderately induces oxidative stress in male Wistar rats after short-term oral treatment.斜石耳菌素经短期口服处理后，可适度诱导雄性 Wistar 大鼠产生氧化应激。
Mycotoxin Res. 2020 May;36(2):181-191. doi: 10.1007/s12550-019-00382-8. Epub 2019 Dec 13.
3
Proapoptotic activity of aflatoxin B and sterigmatocystin in HepG2 cells.黄曲霉毒素B和柄曲霉素在肝癌细胞系HepG2中的促凋亡活性。
Toxicol Rep. 2014 Oct 29;1:1076-1086. doi: 10.1016/j.toxrep.2014.10.016. eCollection 2014.
4
Toxicity of emestrin, a new macrocyclic dithiodioxopiperazine mycotoxin, to mitochondrial function.新型大环二硫二氧哌嗪类真菌毒素恩替米辛对线粒体功能的毒性。
Mycotoxin Res. 1989 Mar;5(1):2-8. doi: 10.1007/BF03192110.
5
Reexamination of respiration-impairing effect of bikaverin on isolated mitochondria.重新检查蝴蝶霉素对分离线粒体呼吸抑制作用。
Mycotoxin Res. 1998 Mar;14(1):19-27. doi: 10.1007/BF02945089.
6
The effects of demethylsterigmatocystin and sterigmatin on ATP synthesis system in mitochondria: A comparison with sterigmatocystin.去甲基杂色曲菌素和桔青霉素对线粒体 ATP 合成系统的影响：与杂色曲菌素的比较。
Mycotoxin Res. 1986 Mar;2(1):33-8. doi: 10.1007/BF03191960.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Formation and disappearance of an endogenous uncoupling factor during swelling and contraction of mitochondria.线粒体肿胀和收缩过程中内源性解偶联因子的形成与消失
Biochim Biophys Acta. 1961 Aug 19;51:442-56. doi: 10.1016/0006-3002(61)90600-x.
3
Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization.氧化磷酸化中的呼吸酶。I. 氧气利用动力学
J Biol Chem. 1955 Nov;217(1):383-93.
4
The osmotic behavior and permeability to non-electrolytes of mitochondria.线粒体的渗透行为及对非电解质的通透性
Arch Biochem Biophys. 1955 Sep;58(1):52-67. doi: 10.1016/0003-9861(55)90092-8.
5
Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.鉴定averantin为黄曲霉毒素B1前体：确定其在生物合成途径中的位置。
Appl Environ Microbiol. 1980 Apr;39(4):835-9. doi: 10.1128/aem.39.4.835-839.1980.
6
7
The interaction of highly active uncouplers with mitochondria.高活性解偶联剂与线粒体的相互作用。
Biochim Biophys Acta. 1981 Dec 30;639(3-4):225-42. doi: 10.1016/0304-4173(81)90011-2.
8
Averufin, an anthraquinone mycotoxin possessing a potent uncoupling effect on mitochondrial respiration.阿维菌素，一种对线粒体呼吸具有强大解偶联作用的蒽醌类霉菌毒素。
Appl Environ Microbiol. 1984 Mar;47(3):481-3. doi: 10.1128/aem.47.3.481-483.1984.
9
Transport of protons across membranes by weak acids.弱酸介导的质子跨膜转运
Physiol Rev. 1980 Jul;60(3):825-63. doi: 10.1152/physrev.1980.60.3.825.
10
Inhibition by secalonic acid D of oxidative phosphorylation and Ca2+-induced swelling in mitochondria isolated from rat livers.大黄素甲醚对从大鼠肝脏分离的线粒体中氧化磷酸化和Ca2+诱导的肿胀的抑制作用。
Appl Environ Microbiol. 1983 Oct;46(4):793-6. doi: 10.1128/aem.46.4.793-796.1983.
Zotero 插件