[Characteristic effects of rabbit liver extract on hepatocyte proliferation in the regenerating liver of mice of various ages].

Chalone isolated by the Verly method was injected into animals of different age (2 groups) under partial hepatectomy. The percentage of hepatocytes in S-, G2-, M- and post-M-periods was determined by morphoautoradiography. These parameters were used for the reconstruction of the extent and dynamics of cell proliferation during 36-48 hours of regeneration. The suppressing effect of chalone on hepatocyte proliferation was more pronounced in young mice. The lack of complete inhibition of DNA synthesis and of the effect of proliferative synchronization was observed in both groups of mice.