Demerson C A, Humber L G, Abraham N A, Schilling G, Martel R R, Pace-Asciak C
J Med Chem. 1983 Dec;26(12):1778-80. doi: 10.1021/jm00366a025.
Etodolac, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, a clinically effective analgesic and antiinflammatory agent, has been resolved via a chromatographic separation of its diastereoisomeric esters with (-)-borneol. The effects of the enantiomers were studied in vitro on prostaglandin synthetase and on adjuvant-induced arthritis in rats. The biochemical and pharmacological results show that virtually all of the effects of etodolac are due to the (+) enantiomer.
依托度酸，即1,8 - 二乙基 - 1,3,4,9 - 四氢吡喃并[3,4 - b]吲哚 - 1 - 乙酸，是一种临床有效的镇痛和抗炎药物，已通过其非对映体酯与（-）-冰片的色谱分离进行拆分。在体外研究了对映体对前列腺素合成酶和大鼠佐剂性关节炎的影响。生化和药理学结果表明，依托度酸的几乎所有作用都归因于（+）对映体。
