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Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs.
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18567-71. doi: 10.1073/pnas.0509316102. Epub 2005 Dec 13.
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R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells.
J Hepatol. 2007 May;46(5):849-57. doi: 10.1016/j.jhep.2006.11.017. Epub 2006 Dec 21.
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Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?
Endocr Rev. 2005 Dec;26(7):898-915. doi: 10.1210/er.2003-0034. Epub 2005 Aug 26.

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Advances in Diclofenac Derivatives: Exploring Carborane-Substituted N-Methyl and Nitrile Analogs for Anticancer Therapy.
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Turkish coffee has an antitumor effect on breast cancer cells in vitro and in vivo.
Nutr Metab (Lond). 2024 Sep 13;21(1):73. doi: 10.1186/s12986-024-00846-4.
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R-etodolac is a more potent Wnt signaling inhibitor than enantiomer, S-etodolac.
Biochem Biophys Rep. 2022 Feb 19;30:101231. doi: 10.1016/j.bbrep.2022.101231. eCollection 2022 Jul.
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Crystal structure of the non-steroidal anti-inflammatory drug (NSAID) tolmetin sodium.
Acta Crystallogr E Crystallogr Commun. 2021 Jan 19;77(Pt 2):134-137. doi: 10.1107/S2056989021000414. eCollection 2021 Feb 1.
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PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis.
Front Endocrinol (Lausanne). 2017 Feb 22;8:31. doi: 10.3389/fendo.2017.00031. eCollection 2017.

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1
The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis.
Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2525-30. doi: 10.1073/pnas.0409721102. Epub 2005 Feb 7.
2
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12682-7. doi: 10.1073/pnas.0404875101. Epub 2004 Aug 16.
3
Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma.
Cancer Cell. 2004 Jun;5(6):565-74. doi: 10.1016/j.ccr.2004.05.014.
7
PPAR gamma signaling exacerbates mammary gland tumor development.
Genes Dev. 2004 Mar 1;18(5):528-40. doi: 10.1101/gad.1167804.
8
Nonsteroidal anti-Inflammatory drugs and cardiovascular risk.
J Am Coll Cardiol. 2004 Feb 18;43(4):519-25. doi: 10.1016/j.jacc.2003.09.043.
9
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia.
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3118-23. doi: 10.1073/pnas.0308648100. Epub 2004 Feb 18.
10
Beta-catenin signaling in prostate cancer: an early perspective.
Endocr Relat Cancer. 2003 Dec;10(4):537-60. doi: 10.1677/erc.0.0100537.

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