在连续选择抗药性的中国仓鼠卵巢细胞中突变率增加。
Increased mutational rates in Chinese hamster ovary cells serially selected for drug resistance.
作者信息
Drobetsky E, Meuth M
出版信息
Mol Cell Biol. 1983 Oct;3(10):1882-5. doi: 10.1128/mcb.3.10.1882-1885.1983.
Abstract
Chinese hamster ovary cell populations exposed to the pressures of prolonged serial cultivation in cytotoxic drugs have increased mutational rates at independent genetic loci. Evidence suggests that the alterations generating these mutations may be independent of the lesions conferring drug resistance.
摘要
暴露于细胞毒性药物中长期连续传代培养压力下的中国仓鼠卵巢细胞群体，在独立的基因位点处的突变率有所增加。有证据表明，产生这些突变的改变可能独立于赋予耐药性的损伤。
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