• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在连续选择抗药性的中国仓鼠卵巢细胞中突变率增加。

Increased mutational rates in Chinese hamster ovary cells serially selected for drug resistance.

作者信息

Drobetsky E, Meuth M

出版信息

Mol Cell Biol. 1983 Oct;3(10):1882-5. doi: 10.1128/mcb.3.10.1882-1885.1983.

DOI:10.1128/mcb.3.10.1882-1885.1983
PMID:6227809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC370049/
Abstract

Chinese hamster ovary cell populations exposed to the pressures of prolonged serial cultivation in cytotoxic drugs have increased mutational rates at independent genetic loci. Evidence suggests that the alterations generating these mutations may be independent of the lesions conferring drug resistance.

摘要

暴露于细胞毒性药物中长期连续传代培养压力下的中国仓鼠卵巢细胞群体，在独立的基因位点处的突变率有所增加。有证据表明，产生这些突变的改变可能独立于赋予耐药性的损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/762e/370049/0635fc6a2093/molcellb00110-0207-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/762e/370049/0635fc6a2093/molcellb00110-0207-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/762e/370049/0635fc6a2093/molcellb00110-0207-a.jpg

相似文献

1
Increased mutational rates in Chinese hamster ovary cells serially selected for drug resistance.在连续选择抗药性的中国仓鼠卵巢细胞中突变率增加。
Mol Cell Biol. 1983 Oct;3(10):1882-5. doi: 10.1128/mcb.3.10.1882-1885.1983.
2
Cytotoxic and mutagenic properties of shale oil byproducts II. Comparison of mutagenic effects at five genetic markers induced by retort process water plus near ultraviolet light in Chinese hamster ovary cells.
Environ Mutagen. 1982;4(4):457-67. doi: 10.1002/em.2860040405.
3
Mutagenic responses of five independent genetic loci in CHO cells to a variety of mutagens. Development and characteristics of a mutagen screening system based on selection for multiple drug-resistant markers.中国仓鼠卵巢细胞（CHO）中五个独立基因位点对多种诱变剂的诱变反应。基于多重耐药标记物选择的诱变筛选系统的开发与特性。
Mutat Res. 1982 Jun;94(2):449-66. doi: 10.1016/0027-5107(82)90307-4.
4
Identification and characterization of a third complementation group of emetine-resistant Chinese hamster cell mutants.对耐吐根碱的中国仓鼠细胞突变体的第三个互补群的鉴定与表征。
Mol Cell Biol. 1981 Jan;1(1):58-65. doi: 10.1128/mcb.1.1.58-65.1981.
5
Mutation induction by 5-fluorodeoxyuridine in synchronous Chinese hamster cells.
Cancer Res. 1979 Mar;39(3):808-10.
6
Biochemical evidence for multiple independent emetine resistance genes in Chinese hamster cells.中国仓鼠细胞中多个独立的吐根碱抗性基因的生化证据。
Mol Cell Biol. 1983 Feb;3(2):198-202. doi: 10.1128/mcb.3.2.198-202.1983.
7
Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cells.亚砷酸钠增强了紫外线对中国仓鼠卵巢细胞的细胞毒性、染色体断裂效应和6-硫代鸟嘌呤抗性诱变性。
Mutat Res. 1985 Jan-Feb;148(1-2):83-9. doi: 10.1016/0027-5107(85)90210-6.
8
Synthesis and incorporation of human ribosomal protein S14 into functional ribosomes in human-Chinese hamster cell hybrids containing human chromosome 5: human RPS14 gene is the structural gene for ribosomal protein S14.人核糖体蛋白S14在含人5号染色体的人-中国仓鼠细胞杂种中合成并整合到功能性核糖体中：人RPS14基因是核糖体蛋白S14的结构基因。
Somat Cell Mol Genet. 1985 Nov;11(6):625-31. doi: 10.1007/BF01534727.
9
Fluctuation analyses of spontaneous mutations to 6-thioguanine resistance in Chinese hamster ovary cells in culture.
Mutat Res. 1981 Jul;82(2):343-53. doi: 10.1016/0027-5107(81)90163-9.
10
Ouabain-resistant mutants of Chinese hamster ovary cells are not directly affected in Na+, K+-ATPase.中国仓鼠卵巢细胞的哇巴因抗性突变体在钠钾ATP酶方面未受到直接影响。
Somat Cell Mol Genet. 1986 Jul;12(4):367-73. doi: 10.1007/BF01570731.

引用本文的文献

1
Mismatch repair deficiency associated with overexpression of the MSH3 gene.与MSH3基因过表达相关的错配修复缺陷
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8568-73. doi: 10.1073/pnas.95.15.8568.
2
Quantitative genetic analysis of tumor progression.肿瘤进展的数量遗传学分析
Cancer Metastasis Rev. 1985;4(2):173-92. doi: 10.1007/BF00050694.
3
Lack of correlation between deoxyribonucleotide pool sizes, spontaneous mutation rates and malignant potential in Chinese hamster ovary cells.中国仓鼠卵巢细胞中脱氧核糖核苷酸池大小、自发突变率与恶性潜能之间缺乏相关性。

本文引用的文献

1
Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts.培养的小鼠成纤维细胞中胸苷酸合成酶基因表达的细胞周期调控
J Biol Chem. 1980 Aug 10;255(15):7386-90.
2
Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools.具有不同生化缺陷和异常脱氧核糖核苷三磷酸库的哺乳动物细胞突变体中的突变体表型。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2447-51. doi: 10.1073/pnas.78.4.2447.
3
Mutagenic deamination of cytosine residues in DNA.DNA中胞嘧啶残基的诱变脱氨基作用。
J Cancer Res Clin Oncol. 1989;115(5):429-34. doi: 10.1007/BF00393331.
4
Spontaneous rearrangement of integrated simian virus 40 DNA in nine transformed rodent cell lines.九个转化的啮齿动物细胞系中整合的猴病毒40 DNA的自发重排。
J Virol. 1989 Jan;63(1):165-74. doi: 10.1128/JVI.63.1.165-174.1989.
5
Increased rate of base substitution in a hamster mutator strain obtained during serial selection for gene amplification.在为基因扩增进行连续选择过程中获得的仓鼠突变株中碱基替换率增加。
Mol Cell Biol. 1990 Dec;10(12):6805-8. doi: 10.1128/mcb.10.12.6805-6808.1990.
Nature. 1980 Oct 9;287(5782):560-1. doi: 10.1038/287560a0.
4
Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells.5-氟脱氧尿苷耐药的培养肝癌细胞中胸苷酸合成酶增加。
Biochem Pharmacol. 1980 Jun 1;29(11):1549-53. doi: 10.1016/0006-2952(80)90607-3.
5
Mutator strains of Escherichia coli, mutD and dnaQ, with defective exonucleolytic editing by DNA polymerase III holoenzyme.大肠杆菌的突变菌株mutD和dnaQ，其DNA聚合酶III全酶的核酸外切酶编辑功能存在缺陷。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2189-92. doi: 10.1073/pnas.80.8.2189.
6
Alterations of gene structure in ethyl methane sulfonate-induced mutants of mammalian cells.甲磺酸乙酯诱导的哺乳动物细胞突变体中的基因结构改变。
Mol Cell Biol. 1982 Nov;2(11):1459-62. doi: 10.1128/mcb.2.11.1459-1462.1982.
7
Transposable elements in Drosophila and other Diptera.果蝇及其他双翅目中的转座元件。
Annu Rev Genet. 1980;14:109-20. doi: 10.1146/annurev.ge.14.120180.000545.
8
Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts.5-氟脱氧尿苷抗性小鼠成纤维细胞中胸苷酸合成酶的过量产生。
Mol Cell Biol. 1982 Sep;2(9):1118-25. doi: 10.1128/mcb.2.9.1118-1125.1982.
9
An isotopic assay for thymidylate synthetase.胸苷酸合成酶的同位素测定法。
Biochemistry. 1966 Nov;5(11):3546-8. doi: 10.1021/bi00875a022.
10
Rapid determination of nucleoside kinase and nucleotidase activities with tritium-labeled substrates.用氚标记的底物快速测定核苷激酶和核苷酸酶活性。
Anal Biochem. 1969 Apr 4;28(1):192-205. doi: 10.1016/0003-2697(69)90170-5.