冷凝集素水平的变化

Variation of cold agglutinin levels.

作者信息

Dube V E, Zuckerman L, Philipsborn H F

出版信息

Vox Sang. 1978;34(2):71-6. doi: 10.1111/j.1423-0410.1978.tb03725.x.

DOI:10.1111/j.1423-0410.1978.tb03725.x

Abstract

Cold agglutinin levels were determined in 120 individuals ranging in age from 1 to 64 years using untreated and ficin-treated group O erythrocytes. The geometric mean titer for untreated cells was 5.7 +/- 1.1 SEM and for ficin-treated cells 18.7 +/- 1.1 SEM. The mean titers and scores for various blood groups were not significantly different. Titers and scores correlated significantly to total serum IgM concentration (p less than 0.001). Females had significantly higher cold agglutinin levels than males (p less than 0.001). A significant decrease of cold agglutinins occurred in the 26- to 64-year age group as compared to the 11- to 25-year age group (p less than 0.01). The data should contribute to a clearer understanding of the biological impact of cold agglutinins.

摘要

使用未经处理和经胰蛋白酶处理的O型红细胞，对120名年龄在1至64岁之间的个体测定冷凝集素水平。未经处理细胞的几何平均滴度为5.7±1.1标准误，经胰蛋白酶处理细胞的几何平均滴度为18.7±1.1标准误。不同血型的平均滴度和分数无显著差异。滴度和分数与血清总IgM浓度显著相关（p<0.001）。女性的冷凝集素水平显著高于男性（p<0.001）。与11至25岁年龄组相比，26至64岁年龄组的冷凝集素显著降低（p<0.01）。这些数据应有助于更清楚地了解冷凝集素的生物学影响。