诺氟沙星在大鼠胃肠道中的抗菌活性。
Antibacterial activity of norfloxacin in the gastrointestinal tracts of rats.
作者信息
Frimodt-Møller P C, Jensen K M, Madsen P O
出版信息
Antimicrob Agents Chemother. 1983 Oct;24(4):560-3. doi: 10.1128/AAC.24.4.560.
The capacities of norfloxacin (MK-0366) and neomycin to reduce the numbers of bacteria in the gastrointestinal tracts of rats were evaluated. Results of a 3-day treatment with norfloxacin were compared with those of a 3-day treatment with neomycin. Both drugs significantly decreased gram-negative and gram-positive bacteria. Norfloxacin effected a significantly greater reduction in numbers of gram-negative bacteria than did neomycin. Norfloxacin also significantly increased the number of anaerobic bacteria. Although neomycin reduced gram-positive bacteria more effectively than did norfloxacin, this difference between the two drugs was not significant. Norfloxacin merits further study for potential as a bowel sterilant.
评估了诺氟沙星（MK-0366）和新霉素减少大鼠胃肠道细菌数量的能力。将诺氟沙星3天治疗的结果与新霉素3天治疗的结果进行了比较。两种药物均显著减少革兰氏阴性菌和革兰氏阳性菌。诺氟沙星对革兰氏阴性菌数量的减少作用显著大于新霉素。诺氟沙星还显著增加了厌氧菌的数量。虽然新霉素比诺氟沙星更有效地减少革兰氏阳性菌，但两种药物之间的这种差异并不显著。诺氟沙星作为肠道消毒剂的潜力值得进一步研究。
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