Bauernfeind A, Petermüller C
Eur J Clin Microbiol. 1983 Apr;2(2):111-5. doi: 10.1007/BF02001575.
The in vitro antibacterial activity of the new quinoline derivative ciprofloxacin (BAY 0 9867) was evaluated in comparison to norfloxacin and nalidixic acid using 495 clinical strains of gram-negative and gram-positive bacteria. The compound was highly active against Enterobacteriaceae, with MICs ranging from 0.008 mg/l to 4 mg/l, whereas the MICs of norfloxacin ranged from 0.03 mg/l to 16 mg/l. All strains of Pseudomonas aeruginosa and Acinetobacter calcoaceticus were inhibited with a concentration of 2 mg/l ciprofloxacin and 32 mg/l norfloxacin. Ciprofloxacin was also active against gram-positive cocci. The MICs for Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus faecalis ranged from 0.008 to 2.0 mg/l. The activity of ciprofloxacin was only slightly influenced by inoculum size, whereas an acid environment caused a noticeable decrease in the activity. Ciprofloxacin would seem to be a promising antibacterial agent for the treatment of urinary tract infection.
使用495株革兰氏阴性和革兰氏阳性临床菌株，将新型喹啉衍生物环丙沙星（BAY 0 9867）与诺氟沙星和萘啶酸进行比较，评估其体外抗菌活性。该化合物对肠杆菌科细菌具有高度活性，MIC范围为0.008 mg/l至4 mg/l，而诺氟沙星的MIC范围为0.03 mg/l至16 mg/l。所有铜绿假单胞菌和乙酸钙不动杆菌菌株在环丙沙星浓度为2 mg/l和诺氟沙星浓度为32 mg/l时受到抑制。环丙沙星对革兰氏阳性球菌也有活性。金黄色葡萄球菌、表皮葡萄球菌和粪肠球菌的MIC范围为0.008至2.0 mg/l。环丙沙星的活性仅受接种量大小的轻微影响，而酸性环境会导致活性明显降低。环丙沙星似乎是治疗尿路感染的一种有前景的抗菌剂。
