Gupta M L, Tandon P, Barthwal J P, Gupta T K, Bhargava K P
Exp Clin Endocrinol. 1983 Nov;82(3):380-3. doi: 10.1055/s-0029-1210303.
The role of catecholamines in the mechanism of antiovulatory and other central effects of medroxyprogesterone acetate (MPA) has been studied in adult healthy, non-pregnant female albino rats. It has been observed that a single dose of MPA (100 mg/kg) given intramuscularly did not cause any significant change in brain catecholamine levels after 7 days of treatment. However, there was a significant reduction in brain dopamine levels after 15 days of MPA administration. This reduction in brain dopamine levels may be responsible for the anti-ovulatory activity of MPA. Certain side effects of MPA such as amenorrhoea, galactorrhoea, breast tenderness, breast tumors, inactivity and depression may also be due to decrease in brain dopamine levels.
在成年健康、未怀孕的雌性白化大鼠中，研究了儿茶酚胺在醋酸甲羟孕酮（MPA）的抗排卵机制及其他中枢作用中的角色。观察到肌肉注射单剂量MPA（100mg/kg），在治疗7天后，脑内儿茶酚胺水平未发生任何显著变化。然而，在MPA给药15天后，脑内多巴胺水平显著降低。脑内多巴胺水平的这种降低可能是MPA抗排卵活性的原因。MPA的某些副作用，如闭经、溢乳、乳房压痛、乳腺肿瘤、活动减少和抑郁，也可能归因于脑内多巴胺水平的降低。
