补体系统中H因子对经典C5转化酶的抑制作用。
Inhibition of classical C5 convertase in the complement system by factor H.
作者信息
Ito S, Tamura N
出版信息
Immunology. 1983 Dec;50(4):631-5.
This paper described the influence of factor H on the haemolytic activity of the classical C5 convertase. Factor H showed little effect on the interaction of C5 with EAC1,4b,2a,3b cells bearing low numbers of C3b sites, but displayed the inhibitory effect on the interaction of C5 with the intermediate cells bearing high numbers of C3b sites. The higher the number of C3b sites on the cells, the greater the degree of the inhibition by factor H. The inhibition by factor H was accompanied by the inhibition of consumption of C5 from the fluid phase, indicating that factor H inhibits the activity of C5 convertase, not the binding of activated C5 to the cells.
本文描述了补体H因子对经典C5转化酶溶血活性的影响。补体H因子对C5与C3b位点数量少的EAC1,4b,2a,3b细胞之间的相互作用影响很小，但对C5与C3b位点数量多的中间细胞之间的相互作用具有抑制作用。细胞上C3b位点的数量越高，补体H因子的抑制程度就越大。补体H因子的抑制作用伴随着液相中C5消耗的抑制，这表明补体H因子抑制C5转化酶的活性，而不是活化的C5与细胞的结合。
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