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人补体第二成分与豚鼠补体第四成分反应中的不相容性。

An incompatibility in the reaction of the second component of human complement with the fourth component of guinea-pig complement.

作者信息

Tamura N

出版信息

Immunology. 1970 Feb;18(2):203-12.

PMID:5416637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455546/
Abstract

An incompatibility in the reaction of human C2 with EAC14 consisting of guinea-pig C4 was demonstrated. Human C2 reacted poorly with EAC14 consisting of guinea-pig C4. The substitution of guinea-pig C4 on EAC14 with human C4 resulted in the fifteen- to twenty-fold increase of the haemolytic activity of C2 in whole human serum. It became more manifest in the titration of purified human C2. Purified human C2 showed about 100 times more activity with EAC14 consisting of human C4, although guinea-pig C2 reacted effectively with EAC14 carrying either guinea-pig or human C4. The unsuitability of the measurement of human C2 employing EAC14 prepared with guinea-pig C4 was shown.

摘要

已证实人C2与由豚鼠C4组成的EAC14反应存在不相容性。人C2与由豚鼠C4组成的EAC14反应较差。用人类C4替代EAC14上的豚鼠C4，可使全人血清中C2的溶血活性提高15至20倍。在纯化的人C2滴定中，这种情况更为明显。纯化的人C2与由人C4组成的EAC14反应时，活性高出约100倍，尽管豚鼠C2与携带豚鼠或人C4的EAC14反应有效。结果表明，使用由豚鼠C4制备的EAC14来检测人C2是不合适的。

相似文献

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本文引用的文献

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The Action of Ammonia on Complement. The Fourth Component.氨对补体的作用。第四成分。
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[The properdin-complement system in various diseases with regard to serum protein and heavy metal].[关于血清蛋白和重金属的各种疾病中的备解素 - 补体系统]
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5
Some properties of an esterase derived from preparations of the first component of complement.源自补体第一成分制剂的一种酯酶的某些特性。
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6
Three naturally-occurring inhibitors of components of complement in guinea pig and rabbit serum.豚鼠和兔血清中补体成分的三种天然存在的抑制剂。
J Immunol. 1967 Sep;99(3):582-9.
7
Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.豚鼠血清中溶血补体九种成分的分离、纯化及测定方法
Immunochemistry. 1966 Mar;3(2):111-35. doi: 10.1016/0019-2791(66)90292-8.
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The isolation and characterization of a new component of hemolytic complement, C'3e.溶血补体新成分C'3e的分离与特性研究
J Immunol. 1965 Aug;95(2):355-67.
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A molecular concept of immune cytolysis.免疫细胞溶解的分子概念。
Arch Pathol. 1966 Sep;82(3):205-17.
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The purification and reactivity of the first component of complement from guinea pig, human and canine sera.豚鼠、人及犬血清中补体第一成分的纯化及反应性
J Immunol. 1968 Dec;101(6):1333-45.

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