Wiebe R H, Morris C V
Obstet Gynecol. 1984 Jan;63(1):12-4.
Seven women with hirsutism (five with polycystic ovarian disease, two with eumenorrheic hirsutism) were studied before and during the fourth and sixth cycles of oral contraceptive treatment (norethindrone/mestranol, 1 mg/0.05 mg). Plasma testosterone, androstenedione, and dehydroepiandrosterone sulfate were measured before and during treatment. Testosterone was reduced 72%, androstenedione was reduced 68.5%, and dehydroepiandrosterone sulfate was reduced 41.25% during therapy. Plasma dehydroepiandrosterone sulfate normalized in all patients with pretreatment elevation of this steroid. Norethindrone/mestranol, 1 mg/0.05 mg is capable of suppressing both ovarian and adrenal androgens in hirsute women with modest elevation of these steroids.
对7名多毛症女性（5名患有多囊卵巢疾病，2名有排卵性多毛症）在口服避孕药（炔诺酮/炔雌醇甲醚，1毫克/0.05毫克）治疗的第四个周期和第六个周期之前及期间进行了研究。在治疗前和治疗期间测量了血浆睾酮、雄烯二酮和硫酸脱氢表雄酮。治疗期间，睾酮降低了72%，雄烯二酮降低了68.5%，硫酸脱氢表雄酮降低了41.25%。所有硫酸脱氢表雄酮预处理时升高的患者，其血浆硫酸脱氢表雄酮均恢复正常。炔诺酮/炔雌醇甲醚，1毫克/0.05毫克能够抑制这些类固醇轻度升高的多毛症女性的卵巢和肾上腺雄激素。
