Meier-Ruge W, Abdel-Al S, Schulz U
Presse Med. 1983 Dec 29;12(48):3115-8.
Stereological investigations of putamen, frontal gyrus and precentral gyrus in Alzheimer's disease and in age-matched controls were performed with an optical electronic image analysis system (Leitz). In all layers of the frontal cortex, a significant atrophy of neuronal perikarya is observed in Alzheimer's disease compared with normally aged specimen. In putamen, a non significant decrease is measured in the area of nerve cells. The morphometric results of the capillary measurements show a 40% increase of the capillary volume in the brain cortex of the Alzheimer group compared with the controls. These results which are probably localized in cortex represent gross atrophy of the frontal brain in senile dementia of the Alzheimer type. No changes of this kind can be observed in young individuals (19-45 years) or the normal aged group (85-95 years).
使用光学电子图像分析系统（徕卡）对阿尔茨海默病患者及年龄匹配的对照者的壳核、额叶回和中央前回进行了体视学研究。与正常老龄标本相比，在阿尔茨海默病患者的额叶皮质各层中均观察到神经元胞体明显萎缩。在壳核中，神经细胞面积有不显著的减少。毛细血管测量的形态学结果显示，与对照组相比，阿尔茨海默病组大脑皮质的毛细血管体积增加了40%。这些可能局限于皮质的结果代表了阿尔茨海默型老年痴呆症患者额叶脑的总体萎缩。在年轻个体（19 - 45岁）或正常老龄组（85 - 95岁）中未观察到此类变化。
