Kawai K, Mori H, Kitamura J
Toxicol Lett. 1983 Dec;19(3):321-5. doi: 10.1016/0378-4274(83)90137-6.
The effects of flavoglaucin from Aspergillus chevalieri (Mangin) Thom et Church on mitochondrial reactions have been investigated to obtain insight into the mode of actions on biomembranes by means of isolated rat liver mitochondria. It was found that flavoglaucin exhibited a strong uncoupling effect on oxidative phosphorylation, enhanced the latent ATPase activity, and elicited a drastic swelling of mitochondria. These reactions led to the exhaustion of ATP in cells, which may be, in part, responsible for its cytotoxicity. Flavoglaucin was toxic to isolated rat hepatocytes causing a karyoklasis, but did not show genotoxicity in hepatocyte primary culture (HPC)/DNA repair test.
研究了来自谢瓦曲霉（Mangin）Thom和Church的黄曲霉素对线粒体反应的影响，以通过分离的大鼠肝线粒体深入了解其对生物膜的作用方式。发现黄曲霉素对氧化磷酸化表现出强烈的解偶联作用，增强了潜在的ATP酶活性，并引起线粒体的剧烈肿胀。这些反应导致细胞内ATP耗尽，这可能部分是其细胞毒性的原因。黄曲霉素对分离的大鼠肝细胞有毒性，可导致核破裂，但在肝细胞原代培养（HPC）/DNA修复试验中未显示出遗传毒性。
