Chan C S, Brown I G, Kelly C A, Dent A G, Zimmerman P V
Br J Clin Pharmacol. 1984 Jan;17(1):103-5. doi: 10.1111/j.1365-2125.1984.tb05008.x.
A placebo controlled study compared the magnitude and duration of bronchodilatation produced by nebulised salbutamol (5 mg) and ipratropium (0.5 mg) singly and in combination in twenty patients with chronic bronchitis (mean baseline FEV1 was 33% predicted). The onset of action, of both nebulised salbutamol and ipratropium given singly, occurred within 15 min. Both agents produced a similar degree of bronchodilatation. In combination both the magnitude and duration of the bronchodilatation produced was significantly greater than with either agent alone.
一项安慰剂对照研究比较了雾化吸入沙丁胺醇（5毫克）和异丙托溴铵（0.5毫克）单独及联合使用时，对20例慢性支气管炎患者（平均基线第一秒用力呼气量预计值为33%）产生的支气管扩张程度和持续时间。单独雾化吸入沙丁胺醇和异丙托溴铵的起效时间均在15分钟内。两种药物产生的支气管扩张程度相似。联合使用时，产生的支气管扩张程度和持续时间均显著大于单独使用任一药物时。
