异丙托溴铵与茶碱在哮喘治疗中的协同作用。
Synergism between ipratropium and theophylline in asthma.
作者信息
Kreisman H, Frank H, Wolkove N, Gent M
出版信息
Thorax. 1981 May;36(5):387-91. doi: 10.1136/thx.36.5.387.
Ipratropium bromide is a bronchodilator whose effect has been compared with beta agonists but not with theophylline. Twelve asthmatics were given four two-week courses of the different combinations of ipratropium (40 micrograms in two puffs), theophylline capsules, and their corresponding placebos in a random, double-blind fashion. There was a significant increase in FEV1 and MMFR 60 minutes after theophylline was administered (p less than 0.05) when measured after one and two weeks of therapy. FEV1 and MMFR were significantly increased (p less than 0.05) 30 and 60 minutes after ipratropium inhalation and this increase was significantly greater when the patient had also been taking theophylline compared with placebo capsules (p less than 0.05). There was no toxicity associated with this combination. The synergism demonstrated may be related to the time sequence of drug administration, mechanical or cellular factors.
异丙托溴铵是一种支气管扩张剂，其效果已与β受体激动剂进行了比较，但未与茶碱进行比较。12名哮喘患者以随机、双盲的方式接受了四个为期两周的疗程，这些疗程包含异丙托溴铵（两喷，共40微克）、茶碱胶囊及其相应安慰剂的不同组合。在治疗1周和2周后测量时，服用茶碱60分钟后，第一秒用力呼气量（FEV1）和最大呼气中期流速（MMFR）显著增加（p<0.05）。吸入异丙托溴铵30分钟和60分钟后，FEV1和MMFR显著增加（p<0.05），并且与服用安慰剂胶囊相比，当患者同时服用茶碱时，这种增加显著更大（p<0.05）。该组合未发现毒性。所显示的协同作用可能与药物给药的时间顺序、机械或细胞因素有关。
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