Rozhanets V V, Rusakov D Iu, Tarasova E V, Val'dman A V
Biull Eksp Biol Med. 1983 Dec;96(12):52-5.
Subchronic (14 days) administration of chlorimipramine and zimelidine, and a new morpholine derivative produces different effects on 3H-imipramine binding with synaptic membranes of the mouse brain. Chlorimipramine increases the concentration of the binding sites (Bmax), zimelidine raises both the Bmax and the dissociation constant, while the new morpholine derivative does not significantly change these characteristics. It has been demonstrated that the changes in the Bmax that occur during prolonged administration of chlorimipramine depend on the method for the obtaining of membrane brain preparations.
氯米帕明、齐美利定以及一种新型吗啉衍生物的亚慢性（14天）给药对3H-氯米帕明与小鼠脑突触膜的结合产生不同影响。氯米帕明增加结合位点的浓度（Bmax），齐美利定同时提高Bmax和解离常数，而新型吗啉衍生物对这些特性没有显著影响。已经证明，氯米帕明长期给药期间发生的Bmax变化取决于制备脑细胞膜制剂的方法。
