Bordiukov M M, Kryzhanovskiĭ G N, Nikushkin E V, Bogdanova E D, Prilipko L L
Biull Eksp Biol Med. 1985 Dec;100(12):686-8.
The development of bemegride-induced generalized epileptic activity in rats was shown to reduce the constant (CB). of specific 3H-diazepam binding with synaptic membranes from 0.23 nM-1 to 0.15 nM-1 and to increase the maximum number of membrane binding sites (Bmax) from 410 fmol/mg protein to 550 fmol/mg protein. It is assumed that the changes of benzodiazepine receptor properties are due to alteration in physico-chemical characteristics of synaptic membrane lipids resulting from the activation of lipid peroxidation.
已表明，贝美格诱导的大鼠全身性癫痫活动的发展会使与突触膜结合的特定3H-地西泮的解离常数（CB）从0.23nM-1降至0.15nM-1，并使膜结合位点的最大数量（Bmax）从410fmol/mg蛋白质增加至550fmol/mg蛋白质。据推测，苯二氮䓬受体特性的变化是由于脂质过氧化激活导致突触膜脂质物理化学特性改变所致。
