Holzhausen C, Murphy S, Birke L I
J Endocrinol. 1984 Feb;100(2):149-54. doi: 10.1677/joe.0.1000149.
Medroxyprogesterone acetate (MPA; 5 micrograms/g body wt) or norethisterone oenanthate (NET-OEN; 4 micrograms/g body wt) was given to lactating female rats by subcutaneous injection 1 day after parturition. Each female suckled ten female pups which had been randomly allocated to her and at 21 days of age the pups were weaned. In this way female pups were exposed to either MPA or NET-OEN via milk during suckling. The patterns of LH and progesterone secretion at pro-oestrus were investigated using radioimmunoassay. When these pups reached adulthood it was found that neonatal exposure to MPA via milk significantly reduced the pro-oestrous LH peak by 45% as well as the total amount (by 27%) of LH secreted during pro-oestrus. Neonatal exposure via milk to NET-OEN had no effect on LH secretion during pro-oestrus. Pro-oestrous progesterone secretion was unaffected by either MPA or NET-OEN treatment.
产后1天，通过皮下注射给哺乳期雌性大鼠注射醋酸甲羟孕酮（MPA；5微克/克体重）或庚酸炔诺酮（NET - OEN；4微克/克体重）。每只雌性大鼠哺育10只随机分配给它的雌性幼崽，幼崽在21日龄时断奶。通过这种方式，雌性幼崽在哺乳期间通过乳汁接触到MPA或NET - OEN。使用放射免疫分析法研究动情前期促黄体生成素（LH）和孕酮的分泌模式。当这些幼崽成年后，发现通过乳汁在新生儿期接触MPA可使动情前期LH峰值显著降低45%，同时使动情前期分泌的LH总量降低27%。通过乳汁在新生儿期接触NET - OEN对动情前期LH分泌没有影响。动情前期孕酮分泌不受MPA或NET - OEN处理的影响。
