Birke L I, Sadler D
Physiol Behav. 1984 Aug;33(2):217-9. doi: 10.1016/0031-9384(84)90102-1.
The effects of altering neonatal levels of progestins on the later development of social play behaviour was studied. Progestin levels were raised in experiment one by administering injections of either progesterone or medroxyprogesterone acetate. This indicated that exposure to either hormone led to reduced levels of social play in juvenile rats of both sexes, confirming earlier reports of lowered levels of play following medroxyprogesterone obtained via maternal milk. In Experiment 2, endogenous progestin levels were lowered by administration of the antiserum to progesterone. The prediction that this should result in raised levels of juvenile play was supported for males, but not for females. Females in Experiment 2 by contrast showed a decrease in play. Possible reasons for this sex difference in response to progesterone antiserum are discussed.
研究了改变新生鼠孕激素水平对其后期社交玩耍行为发展的影响。在实验一中，通过注射孕酮或醋酸甲羟孕酮来提高孕激素水平。这表明，接触这两种激素都会导致雌雄幼鼠的社交玩耍水平降低，证实了早期关于通过母乳摄入甲羟孕酮后玩耍水平降低的报道。在实验二中，通过注射孕酮抗血清来降低内源性孕激素水平。对于雄性幼鼠，该操作会导致玩耍水平提高这一预测得到了支持，但对雌性幼鼠则不然。相比之下，实验二中的雌性幼鼠玩耍水平下降。文中讨论了对孕酮抗血清反应存在这种性别差异的可能原因。
