Decazes J M, Meulemans A, Bure A, Laisne M J, Modai J
Presse Med. 1984 Feb 11;13(5):261-4.
Ten patients with purulent meningitis received 3 intravenous injections of 4 g piperacillin at intervals of 8 hours, in addition to the usual antimicrobial treatment. Piperacillin was assayed in serum and CSF by high performance liquid chromatography. The mean CSF concentration of the drug was 9.2 micrograms/ml and its mean percentage of penetration was 22,7%. There were no significant differences in CSF concentrations between days 2 to 4 (inflamed meninges) and days 10 to 20 (patient cured). It is concluded that piperacillin shows good CSF penetration and could be useful to treat selected cases of meningitis due to Gram-negative bacilli.
10例化脓性脑膜炎患者除接受常规抗菌治疗外，还每隔8小时静脉注射3次4克哌拉西林。采用高效液相色谱法测定血清和脑脊液中的哌拉西林。该药物的脑脊液平均浓度为9.2微克/毫升，平均渗透百分比为22.7%。在第2至4天（脑膜发炎）和第10至20天（患者治愈）之间，脑脊液浓度没有显著差异。结论是哌拉西林具有良好的脑脊液渗透性，可用于治疗某些革兰氏阴性杆菌引起的脑膜炎病例。
