头孢他啶在细菌性脑膜炎患者脑脊液中的渗透情况。
Penetration of ceftazidime into cerebrospinal fluid of patients with bacterial meningitis.
作者信息
Modai J, Vittecoq D, Decazes J M, Wolff M, Meulemans A
出版信息
Antimicrob Agents Chemother. 1983 Jul;24(1):126-8. doi: 10.1128/AAC.24.1.126.
Abstract
Four 2-g doses of ceftazidime were infused intravenously over 30 min at 8-h intervals, first between days 2 and 4 and again between days 11 and 20, in 11 patients with bacterial meningitis undergoing treatment with other antibiotics. Concentrations of ceftazidime in serum and cerebrospinal fluid samples obtained 120 or 180 min after dose 4 were measured by high-pressure liquid chromatography. Concentrations in cerebrospinal fluid ranged from 2 to 30 micrograms/ml, depending on the sampling time and the time elapsed since the onset of the disease.
摘要
11例正在接受其他抗生素治疗的细菌性脑膜炎患者，每隔8小时静脉输注4剂2克的头孢他啶，每次输注时间为30分钟，首次输注在第2天至第4天之间，再次输注在第11天至第20天之间。通过高压液相色谱法测定第4剂后120或180分钟采集的血清和脑脊液样本中头孢他啶的浓度。脑脊液中的浓度范围为2至30微克/毫升，这取决于采样时间和疾病发作后的时间。
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本文引用的文献
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