Carlson C J, Emilson B, Rapaport E
Am Heart J. 1978 Mar;95(3):352-8. doi: 10.1016/0002-8703(78)90367-8.
Six patients with severe medical disorders and profound hypothermia are presented who had elevated total serum creatine phosphokinase (CPK) and CPK-MB isoenzyme activity without clinical or postmortem evidence of acute myocardial infarction. Experiments in dogs indicate that hypothermia reduces total CPK activity in both striated and myocardial muscle resulting in increased serum enzyme activity. These data suggest that profound hypothermia may result in diffuse striated and cardiac muscle cellular injury without evidence of discrete infarction with consequent release of CPK-MB isoenzyme into serum.
本文报告了6例患有严重内科疾病并伴有深度低温的患者，这些患者血清总肌酸磷酸激酶（CPK）及CPK-MB同工酶活性升高，但无急性心肌梗死的临床或尸检证据。犬实验表明，低温可降低横纹肌和心肌中的总CPK活性，从而导致血清酶活性升高。这些数据提示，深度低温可能导致弥漫性横纹肌和心肌细胞损伤，而无离散性梗死证据，进而使CPK-MB同工酶释放入血清。
