Abe T, Morimoto C, Toguchi T, Kiyotaki M, Takeuchi T, Koide J, Asakura H, Tsuchiya M, Homma M
Scand J Immunol. 1983 Dec;18(6):521-30. doi: 10.1111/j.1365-3083.1983.tb00887.x.
The loss of suppressor T-cell function results in an abundant production of autoantibodies in systemic lupus erythematosus (SLE). As a cause of this suppressor T-cell defect, anti-T-cell antibody seems to be of prime importance. On the other hand, anti-T-cell antibodies can be detected in various other autoimmune diseases, but their functional characteristics have not been determined. In the present study, the functional characteristics of anti-T-cell antibody from a selected subgroup of patients with ulcerative colitis (UC) were compared with those from patients with SLE. Anti-T-cell antibody from the patients with SLE reacted with a T8 subset, resulting in a suppressor defect, whereas anti-T-cell antibody from the UC patients reacted primarily with a T4 subset. Functionally, SLE- T cells failed to proliferate in response to concanavalin A, whereas UC- T cells from UC patients failed to proliferate in response to phytohaemagglutinin. In the Ig synthesis system, both SLE- and UC- T cells increased Ig production of B cells. Since UC+ T cells did not contribute to the generation of Con-A-inducible suppressor activity, we believe that serum from the selected subgroup of patients with UC reacted with the inducer T-cell subset.
抑制性T细胞功能丧失导致系统性红斑狼疮（SLE）中自身抗体大量产生。作为这种抑制性T细胞缺陷的一个原因，抗T细胞抗体似乎最为重要。另一方面，在各种其他自身免疫性疾病中也能检测到抗T细胞抗体，但其功能特性尚未确定。在本研究中，将溃疡性结肠炎（UC）特定亚组患者的抗T细胞抗体的功能特性与SLE患者的进行了比较。SLE患者的抗T细胞抗体与T8亚群反应，导致抑制缺陷，而UC患者的抗T细胞抗体主要与T4亚群反应。在功能上，SLE-T细胞对刀豆球蛋白A无增殖反应，而UC患者的UC-T细胞对植物血凝素无增殖反应。在免疫球蛋白合成系统中，SLE-T细胞和UC-T细胞均增加了B细胞的免疫球蛋白产生。由于UC+T细胞对刀豆蛋白A诱导的抑制活性的产生没有作用，我们认为所选UC患者亚组的血清与诱导性T细胞亚群发生了反应。
