Gilbreath M J, Kongchareon S, Wimonwattrawatee T, Phisphumvithi P, Pavanand K
Trans R Soc Trop Med Hyg. 1983;77(6):767-70. doi: 10.1016/0035-9203(83)90285-7.
The effect of mefloquine-HCL, a new 4-quinoline methanol anti-malarial compound, on in vitro blast transformation of human peripheral blood mononuclear cells (MNC) was studied. Mefloquine significantly suppressed lectin-induced blast transformation of MNC from healthy Thai adults but MNC responsiveness in the mixed leucocyte reaction (MLR) and cellular viability were not reduced by the concentrations of mefloquine studied. Both T and non-T MNC responsiveness was lower in cultures containing the drug than in normal control cultures. The addition of serum from individuals on mefloquine chemoprophylaxis caused no significant suppression in the blast transformation assays or the MLR but the data do not rule out any clinically significant in vivo suppressive effect by mefloquine on human cellular immune response.
研究了新型4-喹啉甲醇抗疟化合物盐酸甲氟喹对人外周血单个核细胞（MNC）体外 blast 转化的影响。盐酸甲氟喹显著抑制了健康泰国成年人MNC的凝集素诱导的 blast 转化，但在所研究的盐酸甲氟喹浓度下，MNC在混合淋巴细胞反应（MLR）中的反应性和细胞活力并未降低。在含有该药物的培养物中，T和非T MNC的反应性均低于正常对照培养物。在 blast 转化试验或MLR中，添加来自接受甲氟喹化学预防个体的血清并未引起显著抑制，但这些数据并未排除甲氟喹在体内对人体细胞免疫反应产生任何具有临床意义的抑制作用。
