Thong Y H, Ferrante A, Rowan-Kelly B, O'Keefe D E
Trans R Soc Trop Med Hyg. 1979;73(4):388-90. doi: 10.1016/0035-9203(79)90160-3.
The effect of mefloquine, a new antimalarial compound, on the immune response in mice was studied in vitro and in vivo. Slight inhibition of mitogen-induced lymphocyte proliferative responses was observed at a concentration of 1 microgram/ml, and marked cytotoxicity at 4 microgram/ml. In contrast, a higher proportion of human lymphocytes remained viable at the same concentration of mefloquine. Antibody responses to sheep erythrocytes were impaired in mice receiving a total dose of 60 mg/kg. At this dosage schedule, delayed-type hypersensitivity responses to the same antigen were not affected.
研究了新型抗疟化合物甲氟喹对小鼠免疫反应的体内和体外作用。在浓度为1微克/毫升时，观察到有丝分裂原诱导的淋巴细胞增殖反应受到轻微抑制，而在4微克/毫升时则出现明显的细胞毒性。相比之下，在相同甲氟喹浓度下，较高比例的人淋巴细胞仍保持活力。接受总剂量60毫克/千克的小鼠对绵羊红细胞的抗体反应受损。在此剂量方案下，对相同抗原的迟发型超敏反应未受影响。
