Iadgarov I S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(12):1792-6.
The activity of the sympathoadrenal system (SAS) was studied in 132 patients with central nervous system diseases such as parkinsonism, deforming muscular dystonia (DMD), Huntington's chorea, myopathy and asthenic neurosis. The estimation was based on determinations of urine catecholamine (CA) excretion with the help of the fluorometric method developed by E. Sh. Matlina et. al. (1965). The control group included 50 healthy subjects. The findings obtained confirmed the reported data concerning the role of CA in the pathogenesis of the studied forms of nervous pathology. The study showed a decrease in dopamine excretion (DA) in parkinsonism, its increase in Huntington's chorea and DMD, and insufficiency of SAS activity in myopathy. Furthermore, additional criteria pointing to alterations in the diurnal SAS activity in the patients were revealed. These changes manifested themselves in the disruption of the diurnal rhythm of CA excretion as well as in the deficiency of DOPA and DA synthesis and deposition following a single dose of L-DOPA and nacome.
对132例患有中枢神经系统疾病（如帕金森病、变形性肌营养不良症、亨廷顿舞蹈病、肌病和虚弱性神经症）的患者的交感肾上腺系统（SAS）活性进行了研究。评估是基于采用E. Sh. Matlina等人（1965年）开发的荧光法对尿儿茶酚胺（CA）排泄量的测定。对照组包括50名健康受试者。所获得的研究结果证实了有关CA在上述神经病理学发病机制中作用的报道数据。研究表明，帕金森病患者多巴胺排泄量（DA）减少，亨廷顿舞蹈病和变形性肌营养不良症患者DA增加，而肌病患者SAS活性不足。此外，还发现了表明患者日间SAS活性改变的其他标准。这些变化表现为CA排泄昼夜节律的紊乱，以及单次服用左旋多巴和纳可明后多巴和DA合成及沉积的不足。
