Barkatova V P
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(4):495-503.
The study concerns some results of the catecholamine metabolism in torsion dystonia. The author found certain changes of the excretion of catecholamines that were different in patients with various clinical manifestations of the disease. The most expressed changes were observed in patients with prevalent local regidity of the muscles in the clinical picture. They were seen in significant descrease of the excretion of all catecholamines and DOPA; the most expressed was a decrease of dopamine and adrenalin discharge. Along with this in prevalent torsion spastic hyperkinesis in the clinical picture there was a tendency towards an increase of dopamine excretion (in the absence of DOPA and noradrenalin changes), and a decreased adrenalin excretion. A conclusion is drawn concerning heterogeneity of torsion dystonia that deals with a clinical polymorphism of the disease. The author discusses the pathogenetical significance of the found biochemical disturbances.
该研究关注扭转性肌张力障碍中儿茶酚胺代谢的一些结果。作者发现儿茶酚胺排泄存在某些变化，这些变化在该疾病不同临床表现的患者中有所不同。在临床表现以肌肉局部僵硬为主的患者中观察到最明显的变化。所有儿茶酚胺和多巴的排泄显著减少；最明显的是多巴胺和肾上腺素分泌减少。与此同时，在临床表现以扭转性痉挛性运动过多为主的患者中，多巴胺排泄有增加的趋势（多巴和去甲肾上腺素无变化），而肾上腺素排泄减少。得出了关于扭转性肌张力障碍异质性的结论，该异质性涉及该疾病的临床多态性。作者讨论了所发现的生化紊乱的发病机制意义。
